一、个人简介

胡川，副研究员，硕士生导师。2012-2022年于四川大学华西药学院药剂学系学习并获得理学博士学位。2023年6月引进至成都中医药大学工作。在Science Advances、Advanced Functional Materials, Biomaterials, Acta Pharmaceutica Sinica B, Advanced Drug Delivery Reviews等期刊以第一/通讯作者发表SCI论文约20篇。主持“国家自然科学基金面上项目、国家自然科学基金青年科学基金项目（C类）、国家资助博士后研究人员计划、中华中医药学会（2024-2026年度）青年人才托举工程、四川省自然科学基金青年项目”等项目。

联系方式：huchuan@cdutcm.edu.cn

二、研究方向

1. 微环境响应型递释系统的设计与评价

2. 中药组分病灶适应性多维调控递释系统的设计与评价

三、 近五年部分代表性研究成果

1. Hu Chuan†, Ma Jiaqi†, Chen Xi, Chen Yaxin, Song Yujun, Tang Qingsong, He Xinling, Wang Yitao1,3, Gao Huile*, Zhang Jinming*. Microenvironment-driven transformable self-assembly nanoplatform enables spatio-temporal remodeling for rheumatoid arthritis therapy. Sci Adv, 2025,11: eadu5245. (IF=12.5)

2. Tang Ning^#, Tong Fan^#, Wu Panchenghao^#, Xie Xiaofang^#, Wang Lulu, Yu Miao, Xing Xiaoyun, Wang Honglei, Wang Hao, Gao Huile, Hu Chuan*, Peng Cheng*, Zhou Yang*. Glutathione/Cysteine Dual-Consuming Prodrug Nanoassemblies for Potentiated Gas-Photodynamic Therapy. Adv Funct Mater, 2025, 35: 2503604. (IF=18.5)

3. Hu Chuan^#, Ma Jiaqi^#, Su Ziye, Wang Junyu, Zhang Xueqian, Pang Lin, Qu Yan, Shi Jinfeng*, Zhang Jinming*. Co-delivery of doxorubicin and glycyrrhetinic acid via acid/glutathione dual responsive nano-prodrug with sodium bicarbonate carry-on for advanced combinational cancer treatment. J Colloid Interf Sci. 2025, 687:248-260. (IF=9.4)

4. Hu Chuan^#, He Xinling^#, Gao Huile*, Zhang Jinming*. DELIVER: The core principles for the clinic translation of nanomedicines. Acta Pharm Sin B. 2025, 15(2):1196e1198. (IF=14.5)

5. Fu Li, Su Ziye, Wu Shuyang, Cheng Yanfen, Hu Chuan*, Zhang Jinming*. Redox-responsive hyaluronic acid-celastrol prodrug micelles with glycyrrhetinic acid co-delivery for tumor combination therapy. Chinese Chem Lett, 2025, 36:110227. (IF=9.401)

6. Shi Jinfeng, Wang Yehui, Wu Yihan, Li Jingjing, Fu Chaomei, Li Yi, Xie Xingliang, Fan Xiaohong, Hu Yichen, Hu Chuan*, Zhang Jinming*. Tumor Microenvironment ROS/pH Cascade-Responsive Supramolecular Nanoplatform with ROS Regeneration Property for Enhanced Hepatocellular Carcinoma Therapy. ACS Appl Mater Inter, 2024, 16(6):7576-7592. (IF=9.5)

7. Hu Chuan^#, Song Yujun^#, Zhang Yiwei, He Siqin, Liu Xueying, Yang Xiaotong, Gong Tao, Huang Yuan, Gao Huile*. Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome. Acta Pharm Sin B, 2023, 13(5):2176-2187. (IF=14.5)  

8. Hu Chuan, He Xueqin, Chen Yuxiu, Yang Xiaotong, Qin Lin, Lei Ting, Zhou Yang, Gong Tao, Huang Yuan, Gao Huile*. Metformin mediated PD-L1 downregulation in combination with photodynamic-immunotherapy for treatment of breast cancer. Adv Funct Mater, 2021, 31(11):2007149. (IF=19.000)

9. Yu Wenqi^#, Hu Chuan^#, Gao Huile*. Advances of nanomedicines in breast cancer metastasis treatment targeting different metastatic stages. Adv Drug Deliv Rev, 2021, 178:113909. (IF= 17.873)

10. Hu Chuan, Lei Ting, Wang Yazhen, Cao Jun, Yang Xiaotong, Qin Lin, Liu Rui, Zhou Yang, Tong Fan, Umeshappa Sokke Channakeshava*, Gao Huile*. Phagocyte-membrane-coated and laser-responsive nanoparticles control primary and metastatic cancer by inducing anti-tumor immunity. Biomaterials, 2020, 255:120159. (IF=10.317)